The invention, which relates to the compound premix field, discloses a non-antibiotic biological compound premix. The non-antibiotic biological compound premix includes the following components as raw materials by weight: 30 to 35 parts of a vitamin additive, 40 to 45 parts of a compound trace element, 20 to 30 parts of lysine, 10 to 30 parts of methionine, 10 to 35 parts of threonine, 15 to 20 parts of biologically active antibacterial peptide, 20 to 40 parts of compound enzyme preparation, 10 to 30 parts of compound microecology preparation, 5 to 10 parts of a flavoring agent, 5 to 10 parts of an anti-oxidant, and 40 to 50 parts of a plant extract. According to the invention, the compound enzyme preparation, the microecology preparation, oligosaccharides and morusin that is a plant extract and nutrition repairing agent of the animal intestinal tract are employed. Therefore, the palatability and digestibility of the prepared complete feed are improved, so that yellow and white scour as well as diarrhea of piglets can be effectively prevented; in addition, immunity and disease resistance of the piglets are enhanced, and health care medication for prevention is reduced, so that the piglets can grow faster and be healthier, and the breeding cost can be effectively reduced. Moreover, the meat quality can be improved, and safe and organic food, which is beneficial to health, can be produced.